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关于博云

北京博云华康基因科技有限公司(简称博云华康)位于北京市昌平区西三旗上奥世纪中心A座。博云华康是一家行业内领先的面向生命科学及人类健康领域研究者,提供基于高通量测序和生物信息技术的开发与应用,开展科技服务、医学检测、生物云平台等主体业务的高科技企业。致力于自主开发基因大数据分析方法和高效便捷的基因云计算平台,应用"互联网+基因"的基因数据在线分析系统为国内外科研工作者提供优质全面的科研方案设计、数据挖掘分析和云计算服务。

  公司汇聚了业内多家知名基因科技企业的精英人才,拥有丰富的基因组学研究经验和拥有一支8年以上生物信息分析经验的精英团队。依托丰富的基因组、重测序、RNA等项目经验,独特的科学研究技能和卓越的大数据处理能力,博云华康已与全国多家科研院校开展科研合作;并将致力于协助各研究应用领域合作伙伴更加便利地解读组学数据、获得高价值信息和工具,加速科研和应用成果产生,促进整个生命科技相关各行业的蓬勃发展。公司将不断开拓创新,努力成为基因科技领域的领航人!


团队成员

  

罗龙海  创始人兼执行总裁 

       在基因组学研究领域有10年以上从业及管理经验,是基因科技产业化资深专家。曾任华大科技全球副总裁,掌管泛亚太区科技服务业务。哥本哈根大学在读博士,在Nature、PNAS、NC、GB上发表文章十余篇。


韩祖晶  联合创始人兼技术总监

       在基因组学和生物信息分析领域已有超过8年的研究经验,曾任华大基因RNA信息分析总监,高级信息分析工程师,负责RNA各产品研发工作。在NC、NAR、oncotarget上发表文章多余篇,获得两项国家专利。


ZHIGANG LI   Chief Scientist 首席科学家

RESEARCH EXPERIENCE

Research Associate, McGill University, July.2016- Present

Post-doctoral Scholar, McGill University, Oct.2013-June.2016
        · Non-canonical T Cell Receptor Signaling

        · Immunomodulation to Staphylococcus aureus 

Post-doctoral Scholar, East Carolina University, Oct.2011-Sept.2013
        · Acidosis and G protein-coupled receptor regulates c-Myc oncogene expression and cell metabolism. 

Ph.D student, Chinese Academy of Sciences, Sept.2004-Sept.2011
        · Ethylene receptor signaling regulates plant growth in Arabidopsis.

 

EDUCATION

Doctor of Philosophy, Molecular Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China (2004-2011)
Bachelor of Science,
Biotechnology, Northwest A&F University, Yangling, China (2000-2004)

 

PUBLICATIONS

   Publications in Biomedicine

1. Li Z, Zeppa JJ, Hancock MA, McCormick JK, Doherty TM, Hendy GN, and Madrenas J (2018) Staphylococcal superantigens use LAMA2 as a coreceptor to activate T cells. J Immunol ji1701212; DOI: https://doi.org/10.4049/jimmunol.1701212.

2. Li Z, Levast B, and Madrenas J (2017) Staphylococcus aureus Downregulates IP-10 Production and Prevents Th1 Cell Recruitment. J Immunol 1601336; DOI: https://doi.org/10.4049/jimmunol. 1601336

3. Li Z, Peres AG, Damian AC, Madrenas J (2015) Immunomodulation and disease tolerance to Staphylococcus aureus. Pathogens 4(4):793-815

4. Levast B*, Li Z*, and Madrenas J (2015) The role of IL-10 in microbiome-associated immune modulation and disease tolerance. Cytokine 75(2):291-301 (*co-first author)

5. Feng Y, Zhang N, Jacobs KM, Jiang W, Yang LV, Li Z, Zhang J, Lu JQ, and Hu XH (2014) Polarization imaging and classification of Jurkat T and Ramos B cells using a flow cytometer. Cytometry A 85, 817-826.

6. Li Z, Dong L, Dean E, Yang LV (2013) Acidosis decreases c-Myc oncogene expression in human lymphoma Cells: a role for the proton-sensing G protein-coupled receptor TDAG8. Int. J. Mol. Sci. 14, 20236-20255; doi:10.3390/ijms141020236

7. Dong L*, Li Z*, Yang LV* (2013) Function and signaling of the pH-sensing G protein-coupled receptors in physiology and diseases. Book chapter in "Molecular Genetics of Dysregulated pH Homeostasis", edited by Dr. Jen-Tsan Ashley Chi, Springer Science+Business Media (New York), ISBN 978-1-4939-1682-5, page 45-65. doi: 10.1007/978-1-4939-1683-2_4 (*co-first author)

8. Dong L, Li Z, Leffler N, Asch A, Chi J, Yang LV (2013) Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis. PLoS ONE 8(4): e61991. doi:10.1371/journal.pone.0061991 

9. Zhang Y, Feng Y, Justus CR, Jiang W, Li Z, Lu JQ, Brock RS, McPeek MK, Weidner DA, Yang LV, Hu XH (2012) Comparative study of 3D morphology and functions on genetically engineered mouse melanoma cells. Integr Biol (Camb) 4: 1428-1436

Publications in Plant Signaling

10. Li Z, Chen H, Li Q, Tao J, Bian X, Ma B, Zhang W, Chen S, Zhang J (2015). Three SAUR proteins SAUR76, SAUR77 and SAUR78 promote plant growth in Arabidopsis. Sci Rep. 5:12477. doi: 10.1038/srep12477

11. Cao Y*, Chen H*, Li Z*, Tao J, Ma B, Zhang W, Chen S, Zhang J (2015). Tobacco ankyrin protein NEIP2 interacts with ethylene receptor NTHK1 and regulates plant growth and stress responses. Plant Cell Physiol. 56(4):803-18. doi: 10.1093/pcp/pcv009 (*co-first author)

12. Lei G, Shen M, Li Z, Zhang B, Duan K, Wang N, Cao Y, Zhang W, Ma B, Ling H, Chen S, Zhang J (2011) EIN2 regulates salt stress response and interacts with a MA3 domain-containing protein ECIP1 in Arabidopsis. Plant Cell Environ 34: 1678-1692

13. Chen T, Liu J, Lei G, Liu Y, Li Z, Tao J, Hao Y, Cao Y, Lin Q, Zhang W, Ma B, Chen S, Zhang J (2009) Effects of tobacco ethylene receptor mutations on receptor kinase activity, plant growth and stress responses. Plant Cell Physiol 50: 1636-1650

14. Cao Y, Li Z, Chen T, Zhang Z, Zhang J, Chen S (2008) Overexpression of a tobacco small G protein gene NtRop1 causes salt sensitivity and hydrogen peroxide production in transgenic plants. Sci China C Life Sci 51: 383-390

15. Li Z, Cao Y, Zhang J, Chen S (2008) Characterization of Arabidopsis calreticulin mutants in response to calcium and salinity stress. Prog. Nat. Sci.,18:1219-1224


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